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Because of the substantial risk of seizure associated with clozaril use, caution patients about engaging in any activity where sudden loss of consciousness could cause serious risk to themselves or others e.

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Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongationThis risk may increase if you use certain drugssuch as diureticswater pillsor if you have conditions such as severe sweatingdiarrheaor vomitingTalk to your doctor about using clozapine safely.

Clozaril may cause seizuressomnolencepostural hypotensionmotor and sensory instabilitywhich may lead to falls andconsequentlyfractures or other injuriesFor patients with diseasesconditionsor medications that could exacerbate these effectscomplete fall risk assessments when initiating antipsychotic treatment and recurrently for patients on long-term antipsychotic therapy.

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